![protein scaffold trachea protein scaffold trachea](https://cloudflare2.jove.com/files/ftp_upload/2651/2651fig1.jpg)
ELLIOTT MJ, DE COPPI P, SPEGGIORIN S, et al. Decellularization of trachea with combined techniques for tissue-engineered trachea transplantation. BATIOGLU-KARAALTIN A, OVALI E, KARAALTIN MV, et al. In-vivo characterization of a 3D hybrid scaffold based on PCL/decellularized aorta for tracheal tissue engineering. GHORBANI F, MORADI L, SHADMEHR MB, et al. Tissue engineered airways: a prospects article. FISHMAN J M, WILES K, LOWDELL MW, et al. Trachea transplantation: from laboratory to patient. Key words: tissue engineered trachea, decellularization, tracheal replacement therapy, tracheal reconstruction, extracellular matrix, detergent combined with enzyme method, vacuum-assisted decellularization, sodium dodecyl sulfate With the development of decellularization technology, acellular methods have become more mature, sophisticated and diversified, providing directions and approaches for future clinical tracheal treatment. At present, there are cases of decellularization technology used in clinical tracheal transplantation, but patients have more complications after surgery, and its functions need to be further improved. After surgery, patients do not need to rely on immunosuppressants. Decellularization technology removes the immunogenicity of tissues or organs through physical, chemical and biological enzymes, and effectively retains the extracellular matrix of tissues and organs, providing a supportive environment for remodeling functional trachea. It requires tracheal replacement for airway reconstruction therapy, and the decellularized tracheal matrix prepared by acellular technology in tissue engineering research is an effective way for its treatment. RESULTS AND CONCLUSION: Long tracheal injury is mainly caused by tumor, trauma, stenosis, and infection.
![protein scaffold trachea protein scaffold trachea](https://erj.ersjournals.com/content/erj/55/6/1901200/F2.large.jpg)
METHODS: Using the terms “tissue engineered trachea, decellularization, tracheal reconstruction, tracheal replacement therapy” as key words, CNKI, Wanfang and PubMed database from January 2006 to November 2019 were analyzed and summarized. OBJECTIVE: To review the advantages and disadvantages of different acellular techniques in tissue engineered trachea and their application in tracheal replacement therapy. Tissue engineering tracheal decellularization technology can provide an effective treatment approach for long tracheal injury repair. About author:Wang Zhihao, Master candidate, Yangzhou University School of Clinical Medicine, Yangzhou University Transformation Medical Center, Jiangsu Provincial Key Laboratory of Geriatric Disease Prevention and Treatment with Integrated Traditional Chinese and Western Medicine, Yangzhou 225001, Jiangsu Province, ChinaīACKGROUND : Repair of long tracheal injury has always been a major challenge in tracheal therapy.Shi Hongcan, Chief physician, Professor, Doctoral supervisor, Yangzhou University School of Clinical Medicine, Yangzhou University Transformation Medical Center, Jiangsu Provincial Key Laboratory of Geriatric Disease Prevention and Treatment with Integrated Traditional Chinese and Western Medicine, Yangzhou 225001, Jiangsu Province, China Yangzhou University School of Clinical Medicine, Yangzhou University Transformation Medical Center, Jiangsu Provincial Key Laboratory of Geriatric Disease Prevention and Treatment with Integrated Traditional Chinese and Western Medicine, Yangzhou 225001, Jiangsu Province, China